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The two-time Oscar winner, on to promote his forthcoming film, "Captain Phillips," reported that he had suffered from symptoms of Type 2 diabetes (which occurs when the body doesn’t produce enough insulin to function properly) for two full decades, but only received his diagnosis very recently.

The topic came up almost by chance, when Letterman host complimented Hanks on his appearance, noting the star seemed a bit trimmer. Hanks said he had a ways to go to meet his doctor's original goal.

"My doctor said, 'If you can weigh what you weighed in high school, you'll essentially be healthy and not have Type 2 diabetes," Hanks explained before noting that it was an impossible task. "Well, I'm gonna have Type 2 diabetes because there is no way I can weigh as much as I did in high school," he laughed.

When Letterman asked how much the star had weighed back in the day, Hanks didn't miss a beat. "96 pounds," he quipped. "I was a very skinny boy." And how.

Speaking exclusively to Yahoo Movies on Tuesday, Hanks went into more detail about his diagnosis — and his good prognosis.

"Hey, I don't have Type 1 diabetes! Type 1 diabetes is a really, really serious thing. I don't have that. I have high blood sugars and Type 2 diabetes is not going to kill me," explained Hanks. "But I just have to eat right, and exercise, and lose weight, and watch what I eat, and I will be fine for the rest of my life.

"Part of it's hereditary, without a doubt. I guess I just got it in me. But it's really about a lifestyle, man. ...I'm 57 years old and for the last 20 years I've been carrying around probably 15 or 20 extra pounds in my regular life. When I work, a lot of times I have to lose weight and I do that, but in my regular life I was not eating right, and I was not getting enough exercise. But by the nature of my diet and that lifestyle — boom!

"The end result was high blood sugars that reach the levels where it becomes Type 2 diabetes. I share that with a gajillion other people. The best thing you can do that for that and the thing that will completely negate its effects is eat right and lose weight. So that's all I'm doing."